g-iggle:

lolsofunny:

ladderboss:

wtf kind of turtle is that

science of tumblr can you please explain this

mitochondria

I would have gone with smooth endoplasmic reticulum

g-iggle:

lolsofunny:

ladderboss:

wtf kind of turtle is that

science of tumblr can you please explain this

mitochondria

I would have gone with smooth endoplasmic reticulum

(Source: i-justreally-like-cats-okay, via thinksnake)

Tags: gif warning

meshinator:

AIR FORCE HUA

So this is what tone abet just spent $12.4b on?

meshinator:

AIR FORCE HUA

So this is what tone abet just spent $12.4b on?

(via ladylokilexi)

genalovestoons:

orangeyouellis:

I love these new "type these words into your tags box and post the first tag that automatically pops up" thingies, so fun. Let’s do another one:

  • can’t
  • don’t
  • first
  • help
  • please
  • one
  • my
  • will
  • stop
  • get
  • honestly
  • I’m

Instead of going for the first, I think I’m gonna go for the most bizarre ones to pop up.

…and now I’m gonna see where they lead to.

(via eggplantcrusader)

hexiva:

tomibunny:

softgrungenitori:

edgebug:

sincerely, a person who has been on prozac for 9 years

this is in response to some shitty stuff i’ve seen on my dash recently. it’s super simplified, so if you’d like to know some more indepth stuff on how exactly it works, google it—OR BETTER YET actually talk to a mental health doctor psychiatrist person wow

NEVER call my sertraline a “happy pill”
It is a pill that helps my brain function healthily with an important neurotransmitter.
Also you do realize it’s a slow acting medication right?? Like its effects are incredibly delayed. I have about a week long processing time: I know because I could feel them when they had an effect for the very first time vs the day I started them. Now if I miss a day it’s not going to make everything horrid, but I will feel it in a week as a more difficult day for just functioning as a living being.
It doesn’t numb me nor does it make everything sunshine and daisies. It helps my brain work as it should.

Not to mention Prozac and Zoloft both function as pills for OCD, anxiety, and eating disorders, because they’re not “happy pills”. They don’t make you happy. They decrease tendencies towards repetitive actions and compulsions, and Prozac is used for eating disorders because it increases appetite. All it does is adjust chemicals, which does not make people “happy”. 
In fact, if someone were to overdose on Prozac or Zoloft, or abuse it when they don’t have depression (or take too much if they do), it would cause irritable mood swings, an increase in depression, or suicidal thoughts, which should basically prove they aren’t happy pills. 

They just work towards making a brain work in the neurotypical way. 

IDK about SSRIs, but SSNRIs, which is what I’m on, are addictive - or at least cause withdrawal when you go off them. But aside from that, yes, this.

I hope you don’t mind if I jump in here with a little bit of science (I’m doing a PhD in neuroscience and serotonin (or as I call it, 5-HT) is my pet transmitter).

Depression isn’t actually caused by SERT being over active. There is a known gain-of-function mutation that makes SERT more efficient, and it actually causes autism. The 5-HT mediated effects of depression are more likely to be caused by insufficient activity of TPH2, the enzyme that makes neuronal 5-HT. So yes, there is less 5-HT available, and SSRI’s allow for better use of it.

There is evidence now that the delay in SSRI’s taking effect is due to the time it takes to regenerate neurons in the hippocampus. I’m not sure about the CNS because I’m a peripheral neuroscientist, but in the gut, 5-HT is super super important to neuron differentiation. That overactive SERT mutation I mentioned? MASSIVE GUT SIDE EFFECTS. In fact, 80% of people with ASD have altered gastrointestinal function.

And while we’re on the topic of gut, it’s the source of over 90% of all the serotonin in your body. Your big brain (CNS) only makes around 2-5% of it. One of the most common side effects of SSRI antidepressants is dysmotility (gut not working properly - going too fast or too slow, ie diarrhoea or constipation).

Only 65% of people will get the right antidepressant for them the first time around. The success rate goes up to 85% if they try other ones, but many people quit trying before they find the right one because it takes so long for them to kick in. They’re working on ways to get the hit rate up first go, but until then, if your first antidepressant doesn’t work, don’t lose hope, please try another one out.

As for the SSNRI - it’s blocking noradrenaline reuptake as well as serotonin. Probably the most famous noradrenaline reuptake inhibitor is cocaine, so not surprised it’s a little more addictive than a standard SSRI.

And pharmacology of serotonin, dopamine, and noradrenaline all have a bit of overlap, plus the CNS is gross and squishy and three-dimensional and complicated, so the action of an SSRI is not necessarily limited specifically to 5-HT.

Okay that was kinda word vomit but seriously you guys I love 5-HT and am happy to answer any questions anyone might have to the best of my ability.

(via ladylokilexi)

Tags: gif warning

tennantbutt:

pandorica-jar:

Steven Moffat and the Doctors.

you mean peter davison and 3 irrelevants

tennantbutt:

pandorica-jar:

Steven Moffat and the Doctors.

you mean peter davison and 3 irrelevants

(via milokerrigan)

rollinmoses said: Don’t you mean former friend?

Yeah, he’s gone now. He’s the proprietor of Superheroes and Supplements in Newtown, incidentally.

Tags: rollinmoses

Male friend on fb posts a link to an article entitled “most women don’t deserve a good man”. Article is piece of shit slut-shaming misogynist filth, or as he calls it, “damn brilliant article”. Several female friends respond with eloquent criticism the article. Other males jump in and say they’d love to have an adult discussion once the females in the conversation have stopped being childish. Females respond, remaining mature and they do not resort to personal attacks. Original male says he’d like to learn how to stop misogyny, then calls feminists misandrists, says there is too much oestrogen flying around, and leaves us.

Original male makes several statuses asserting that he is neither misogynist nor sexist, that if people don’t like his strong opinions, they shouldn’t be his friend, and thanks his friends for all the supportive messages he got for standing up to those crazy women who were attacking him.

tl;dr send feminism and kittens.

mttyshealy:

LETS PLAY THE “TYPE THESE WORDS IN YOU R TAG BOX AND POST THE FIRST AUTOMATIC TAG THAT COMES UP” GAME: DIRTY WORD ADDITION OK

  • fuck
  • shit
  • dick
  • no
  • hell
  • sex
  • damn

(via rubitan)